NAVIFY® Mutation Caller

Secondary analysis purpose-built for Roche Sample Prep Reagents


A cloud-based secondary analysis solution with next-generation sequencing variant calling methods to support the Roche KAPA portfolio of Sample Prep Reagents.

NAVIFY® Mutation Caller*

Secondary analysis purpose-built for Roche Sample Prep Reagents


A cloud-based secondary analysis solution with next-generation sequencing variant calling methods to support the Roche KAPA portfolio of Sample Prep Reagents.

Save time in pipeline selection and optimization

The Roche KAPA Library Preparation and Target Enrichment kits have been optimized to enable targeting of difficult-to-capture regions and offer greater capture uniformity within a streamlined workflow for your clinical research needs. Now with NAVIFY Mutation Caller, performance optimization has been extended further downstream to offer a secondary analysis solution explicitly tuned for the Roche Sample Prep Portfolio human catalog and custom panels for both KAPA HyperCap and KAPA HyperPETE* workflows.

NAVIFY Mutation Caller offers pipelines for all human custom HyperPETE and HyperCap panels, in addition to the following catalog panels:

  • KAPA HyperPETE Pan Cancer Panel
  • KAPA HyperPETE Hot Spot Panel
  • KAPA HyperPETE Hereditary Oncology Panel
  • KAPA HyperPETE Lung Cancer Fusion Panel
  • KAPA HyperPETE Newborn Screening Panel (not available in the U.S.)
  • KAPA HyperCAP Hereditary Panel

Streamlined secondary analysis

NAVIFY Mutation Caller provides variant calling algorithms that have been selected based on their sensitivity and specificity for Roche Sample Prep reagents. However, clinical research labs can further fine-tune parameter settings to fit their specific wet lab workflow and chosen sequencing coverage as needed. Genotype concordance to reference samples further empowers the lab to assess performance and fine-tune settings. Once pipeline parameter settings are fixed and saved, lab technicians and scientists can efficiently process samples and review results with quick turnaround times.

More than just secondary analysis

With a user-friendly interface, NAVIFY Mutation Caller enables administrators to easily onboard new KAPA human custom panels, as well as to better manage users. Additional capabilities are built in the software to enhance the user experience:

  • Re-run samples
  • Search samples
  • Filter variants
  • View variant annotations
  • Access audit logs
  • View QC metrics

To compare the performance of your existing secondary pipeline to pipelines offered in NAVIFY Mutation Caller, or to hit the ground running in the analysis of newer Roche KAPA custom or catalog panels you are onboarding for your research, request a demo or software trial version today.

Pair with NAVIFY Mutation Profiler for somatic oncology studies

Interpret KAPA HyperPETE somatic panel studies by importing NAVIFY Mutation Caller results into NAVIFY Mutation Profiler*

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A female physician/diagnostician stands in front of a stylized helix, banner image for KAPA HyperPETE Workflow (secondary analysis)

Learn more about KAPA HyperPETE – high performance, time-efficient hybrid-capture target enrichment.

Learn more U.S. Only | Outside the U.S.

A male physician/diagnostician stands in front of a stylized helix, banner image for HyperDesign (secondary analysis)

Learn more about the HyperDesign Tool, a custom design tool that simplifies and streamlines custom panel designs.

Learn more U.S. Only | Outside the U.S.

Worldwide, KAPA HyperPETE Sample Prep Reagents and NAVIFY Mutation Caller are for Research Use Only. Not for use in diagnostics procedures.
*In the US, NAVIFY Mutation Profiler, NAVIFY Mutation Caller, NAVIFY Therapy Matcher app and NAVIFY Clinical Trial Matcher app are for Research Use Only. Not for use in diagnostic procedures.